December 2022Volume 175, Issue 12

ORIGINAL RESEARCH

1. Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers

- A Randomized Trial

2. Contact Tracing and Exposure Investigation in Response to the First Case of Monkeypox Virus Infection in the United States During the 2022 Global Monkeypox Outbreak

3. Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis

- A Randomized Controlled Trial

4. Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations

- A Randomized, Multicenter Trial

5. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease

- A Randomized Controlled Trial

6. Participant Recruitment From Low- and Middle-Income Countries for Pivotal Trials of Drugs Approved by the U.S. Food and Drug Administration

- A Cross-Sectional Analysis

7. Comparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2

- A Secondary Analysis From a Serial Home Self-testing Study

8. Effectiveness of mRNA COVID-19 Vaccine Boosters Against Infection, Hospitalization, and Death: A Target Trial Emulation in the Omicron (B.1.1.529) Variant Era

9. Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy

- A Cohort Study

10. Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial

REVIEWS

11. Characteristics of High-Need, High-Cost Patients

- A “Best-Fit” Framework Synthesis

BEYOND THE GUIDELINES

12. How Would You Manage This Patient With Chronic Insomnia?

- Grand Rounds Discussion From Beth Israel Deaconess Medical Center

POSITION PAPERS

13. Health Care During Incarceration: A Policy Position Paper From the American College of Physicians

SPECIAL ARTICLES

14. Monkeypox: Challenging Clinical Questions

IDEAS AND OPINIONS

15. When States Step Up: California and the Case for State-Led Insulin Manufacturing

16. Endemic Mycoses: Underdiagnosed and Underreported

17. Retiring the “Against Medical Advice” Discharge

EDITORIALS

18. Comparative Effectiveness of Mask Type in Preventing SARS-CoV-2 in Health Care Workers: Uncertainty Persists

19. Ankle Osteoarthritis: Successful Completion of a Challenging Clinical Trial Comparing Surgical Treatments

20. Identifying High-Need, High-Cost Patients: A Real-World Perspective

LETTERS

21. Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States

- Observations: Brief Research Reports

22. Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study

- Observations: Brief Research Reports

23. A Longitudinal Study of COVID-19 Sequelae and Immunity

- Comment

- Response

24. Cardiovascular Outcomes in Patients Initiating First-Line Treatment of Type 2 Diabetes With Sodium–Glucose Cotransporter-2 Inhibitors Versus Metformin

- Comment

- Response

25. Prevention and Initial Management of HIV Infection

- Comment

- Response

CORRECTIONS

26. Correction: The Fall of the Nation's First Gender-Affirming Surgery Clinic

THANKS TO REVIEWERS

27. Thanks to Reviewers—2022

IN THE CLINIC

28. Monoclonal Gammopathy of Undetermined Significance

ACP JOURNAL CLUB

29. In generally healthy adults, supplemental vitamin D3 did not reduce fractures vs. placebo at 5 y

30. In ischemic left ventricular systolic dysfunction, adding PCI to medical therapy did not reduce death or HF hospitalization

31. In acute decompensated HF, adding acetazolamide to IV loop diuretics reduced congestion at 3 d

32. In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality

33. BP-lowering drugs reduced major CV events by similar amounts in patients with and without type 2 diabetes

34. In the general population, salt substitutes vs. regular salt reduce BP levels, CV outcomes, and mortality

35. In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y

36. In THA or TKA, risk for symptomatic VTE was higher with aspirin vs. enoxaparin at 90 d

37. In monkeypox, risk for some symptoms was greater in MSM with vs. without receptive anal contact

38. In adults, risk for infective endocarditis varied for invasive dental procedures and by antibiotic prophylaxis

WEB EXCLUSIVES

39. Annals Graphic Medicine - The COVID-19 Pandemic: A Graphic Narrative

40. Annals Graphic Medicine - Please Welcome the Class of 2024 to the Wards

41. Annals for Educators - December 2022

42. Annals for Hospitalists Inpatient Notes - The Future of Hospital-at-Home Care

SUMMARIES FOR PATIENTS

43. Summary for Patients: Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis

44. Summary for Patients: Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers