Volume 150, Issue Supplement 3 (Dec-22)

Synopsis Book: Best Articles Relevant to Pediatric Allergy, Asthma and Immunology

Supplement Article

1. Title Page

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2. Section on Allergy and Immunology

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3. About This Synopsis Book

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4. A Synopsis of the Synopses, 2021–2022

Allergy
Risk Factors and Prevention of Atopy

5. Infant Gut Microbiome is Enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites With Traditional Farming Lifestyle

6. Increased Food Diversity in the First Year of Life is Inversely Associated with Allergic Outcomes in the Second Year

7. Inverse Associations Between Food Diversity in the Second Year of Life and Allergic Diseases

8. Increasing Severity of Early-onset Atopic Dermatitis, but Not Late-onset, Associates With Development of Aeroallergen Sensitization and Allergic Rhinitis in Childhood

9. Effect of Vitamin D Supplementation on Total and Allergen-specific IgE in Children With Asthma and Low Vitamin D Levels

10.Prevalence of Type 2 Inflammatory Diseases in Pediatric Patients With Atopic Dermatitis: Real-world Evidence

11. Increased Risk of Asthma at Age 10 Years for Children Sensitized to Multiple Allergens

Anaphylaxis

12. Use of Multiple Epinephrine Doses in Anaphylaxis: A Systematic Review and Meta-analysis

13. Anaphylaxis and Pregnancy: A Systematic Review and Call for Public Health Actions

Drug Allergy

14. Establishing Amoxicillin Allergy in Children Through Direct Graded Challenge (GOC): Evaluating Risks Factors for Positive Challenges, Safety, and Risk of Cross-Reactivity to Cephalosporins

15. Safety and Efficacy of Rapid Drug Desensitization in Children

16. Single-step Direct Drug Provocation Testing is Safe for Delabelling Selected Non−low-risk Penicillin Allergy Labels

17. Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis Overlap in Pediatric Patients With a Focus on Newer Antiepileptic Drugs: A 25-year Retrospective Study at a Single Tertiary Care Center

Allergic Rhinitis

18. Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children Through Leptin and Interleukin-1 β

19. Efficacy of Medical Treatments for Vernal Keratoconjunctivitis: A Systematic Review and Meta-analysis

20. Risk Factors for Fatal and Nonfatal Reactions to Immunotherapy (2008–2018): Postinjection Monitoring and Severe Asthma

Allergic Skin Diseases

21. Atopic Dermatitis Trajectories to Age 8 Years in the GUSTO Cohort

22. Childhood Atopic Dermatitis is Associated With Cognitive Dysfunction: A National Health Interview Survey Study From 2008 to 2018

23. Parent Report of Sleep Health and Attention Regulation in a Cross-sectional Study of Infants and Preschool-aged Children With Atopic Dermatitis

24. Vascular Inflammation in Moderate-to-Severe Atopic Dermatitis is Associated With Enhanced Th2 Response

25. Efficacy and Safety of Ruxolitinib Cream for the Treatment of Atopic Dermatitis: Results From 2 Phase 3, Randomized, Double-blind Studies

26. Age-related Differences in Patch Testing Results Among Children: Analysis of North American Contact Dermatitis Group Data, 2001–2018

Food Allergy
IgE-Mediated Food Allergy

27. African American Children Are More Likely to Be Allergic to Shellfish and Finfish: Findings From FORWARD, a Multisite Cohort Study

28. Natural History of IgE-Mediated Fish Allergy in Children

29. Characterizing Biphasic Food-Related Allergic Reactions Through a US Food Allergy Patient Registry

30. Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breast-feeding: A Systemic Review

31. Doses of Specific Allergens in Early Introduction Foods for Prevention of Food Allergy

32. Diagnostic Accuracy of Ara h 2 for Detecting Peanut Allergy in Children

33. Accurate and Reproducible Diagnosis of Peanut Allergy using Epitope Mapping

34. Development and Validation of the Food Allergy Severity Score

35. Peanut Cross-contamination in Randomly Selected Baked Goods

36. Differences in Oral Food Challenge Reaction Severity Based on Increasing Age in a Pediatric Population

37. Tolerance Development in Cow’s Milk-allergic Infants Receiving Amino-acid Based Formula: A Randomized Controlled Trial

38. Efficacy and Safety of Oral Immunotherapy in Children Aged 1 to 3 Years With Peanut Allergy (the Immune Tolerance Network IMPACT Trial): A Randomized Placebo-Controlled Study

39. Real-world Peanut OIT in Infants May be Safer than Noninfant Preschool OIT and Equally Effective

40. Open-label Follow-on Study Evaluating the Efficacy, Safety, and Quality of Life With Extended Daily Oral Immunotherapy in Children With Peanut Allergy

41. Efficacy and Safety of Baked Milk Oral Immunotherapy in Children With Severe Milk Allergy: A Randomized, Double-blind, Placebo-controlled Phase 2 Trial

Non-IgE Mediated Food Allergy

42. Frequency of Guideline-defined Cow's Milk Allergy Symptoms in Infants: Secondary Analysis of EAT Trial Data

43. The Effects of Patient Demographics on Outpatient Endoscopy Utilization in Children With Eosinophilic Esophagitis

44. Neonatal Antibiotics and Food Allergy are Associated With FGIDs at 4 to 6 Years of Age

Asthma
Epidemiology and Risk Factors

45. Childhood Asthma Incidence, Early and Persistent Wheeze, and Neighborhood Socioeconomic Factors in the ECHO/CREW Consortium

46. US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention

47. Worldwide Trends in the Burden of Asthma Symptoms in School-aged Children: Global Asthma Network Phase I Cross-sectional Study

48. Antibiotic Exposure During Pregnancy and Childhood Asthma: A National Birth Cohort Study Investigating Timing of Exposure and Mode of Delivery

49. Evidence for Causal Associations Between Prenatal and Postnatal Antibiotic Exposure and Asthma in Children

50. Association Between Asthma and Sugar-Sweetened Beverage Consumption in the United States Pediatric Population

51. Fruit, Vegetable, and Dietary Antioxidant Intake in School Age, Respiratory Health up to Young Adulthood

52. Childhood Food Allergy and Food Allergen Sensitisation are Associated With Adult Airways Disease: A Birth Cohort Study

53. Intake of n-3 Polyunsaturated Fatty Acids in Childhood, FADS Genotype and Incident Asthma

54. High Insulin in Early Childhood Is Associated With Subsequent Asthma Risk Independent of Body Mass Index

55. Maternal Preconception Occupational Exposure to Cleaning Products and Disinfectants and Offspring Asthma

56. Parental Socioeconomic Status and Asthma in Children: Using a Population-based Cohort and Family Design

57. Late Preterm Infants With Severe Bronchiolitis and Risk of Asthma by Age 5 Years

58. Pneumonia in Infancy and Risk for Asthma: The Role of Familial Confounding and Pneumococcal Vaccination

59. Factors Associated With Persistence of Severe Asthma From Late Adolescence to Early Adulthood

Diagnosis and Management

60. Implementing Spirometry and Fractional Exhaled Nitric Oxide Testing in Childhood Asthma Management in UK Primary Care: An Observational Study to Examine Training and Implementation Cost and Impact on Patient’s Health Use and Outcome

61. Association of Mold Levels in Urban Children’s Homes With Difficult-to-control Asthma

62. Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Study

63. Air Pollutants and Asthma Hospitalization in the Medicaid Population

64. Thunderstorm Asthma in Seasonal Allergic Rhinitis: The TAISAR Study

65. COVID-19 Pandemic-Related Reductions in Pediatric Asthma Exacerbations Corresponded With an Overall Decrease in Respiratory Viral Infections

66. Oncostatin M Expression Induced by Bacterial Triggers Drives Airway Inflammatory and Mucus Secretion in Severe Asthma

67. Association Between Asthma Control Trajectories in Preschoolers and Disease Remission

68. Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans

69. Prospective Study of Disease Persistence and Lung Function Trajectories of Childhood Asthma

70. Preparedness for Pediatric Office Emergencies: A Multicenter, Simulation-Based Study

71. Airway Immune Mediator Levels During Asthma-Like Symptoms in Young Children and Their Possible Role in Response to Azithromycin

72. Stress Ulcer Prophylaxis for Critical Asthma

73. Safety of Live Attenuated Influenza Vaccine in Children With Asthma

74. Physical Activity and Childhood Asthma Control: Mediation and Moderation Role of Body Mass Index

75. Associations of Snoring and Asthma Morbidity in the School Inner-City Asthma Study

76. Pediatric Sleep Questionnaire Predicts More Severe Sleep Apnea in Children With Uncontrolled Asthma

77. Mental Well-Being and General Health in Adolescents With Asthma: The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort Study

Treatment

78. Treatment by Biomarker-informed Endotype Versus Guideline Care in Children With Difficult-to-treat Asthma

79. Efficacy of Inhaled Salbutamol With and Without Prednisolone for First Acute Rhinovirus-induced Wheezing Episode

80. Methylprednisolone, Dexamethasone, or Hydrocortisone for Acute Severe Pediatric Asthma: Does It Matter?

81. Pragmatic Randomized Trial of Corticosteroids and Inhaled Epinephrine for Bronchiolitis in Children in Intensive Care

82. Efficacy and Safety of As-Needed Budesonide-Formoterol in Adolescents With Mild Asthma

83. Adherence to Inhaled Corticosteroids Prescribed Once versus Twice Daily in Children With Asthma

84. Triple versus Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis

85. Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma

86. Efficacy and Safety of Itepekimab in Patients With Moderate-to-Severe Asthma

Immunology

87. Clinical Features in a Large Cohort of Patients With 22q11.2 Deletion Syndrome

88. X-linked Agammaglobulinemia: Infection Frequency and Infection-Related Mortality in the USIDNET Registry

89. Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis

90. Lower Airway Nitrogen Oxide Levels in Children With Primary Ciliary Dyskinesia is Linked to Neutrophilic Inflammation

91. Treatment of Relapsing HPV Diseases by Restored Function of Natural Killer Cells

92. Telemedicine for Children With Medical Complexity: A Randomized Clinical Trial

Coronavirus Disease 2019 (Covid-19)

93. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios

94. Clinical and Laboratory Characteristics of Children With SARS-CoV-2 Infection

95. Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers

96. SARS-CoV-2−Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals

97. Profound Dysregulation of T cell Homeostasis and Function in Patients With Severe COVID-19

98. Parents’ Intentions and Perceptions About COVID-19 Vaccination for Their Children: Results From a National Survey

99. Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes

100. Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel

101. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes

102. Treatment of Multisystem Inflammatory Syndrome in Children

103. Antibody Responses to the SARS-CoV-2 Vaccine in Individuals With Inborn Errors of Immunity

104. Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants With Down Syndrome

105. Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection

- Table of Contents